Table 2.

Cox-proportional hazards regression model showing the impact of aortic valve calcium score on long-term mortality (for the entire cohort, stratified by sex and year of TAVR procedure)

TAVR year	Patients	N	Deaths	Follow-Up (Years) *	cHR (95% CI) †	P-value	aHR (95% CI) ‡	P-value
All Patients (2010 – 2021)
	All	2543	801	2.30 (0.99, 4.17)	1.04 (1.02, 1.06)	<0.001	1.06 (1.02, 1.11)	0.004
	Male	1502	478	2.17 (0.90, 4.07)	1.03 (1.00, 1.06)	0.090	1.02 (0.99, 1.06)	0.24
	Female	1041	323	2.51 (1.12, 4.33)	1.07 (1.02, 1.11)	0.002	1.07 (1.02, 1.12)	0.004
2010 - 2016
	All	956	549	4.68 (2.21, 5.89)	1.04 (1.01, 1.07)	0.004	1.04 (0.99, 1.10)	0.14
	Male	551	321	4.66 (2.04, 5.81)	1.03 (1.00, 1.07)	0.059	1.02 (0.98, 1.06)	0.37
	Female	405	228	4.77 (2.69, 5.96)	1.05 (1.00, 1.10)	0.049	1.07 (1.01, 1.13)	0.030
2017 - 2021
	All	1,587	252	1.69 (0.78, 2.84)	1.04 (1.00, 1.08)	0.081	1.10 (1.03, 1.17)	0.006
	Male	951	157	1.60 (0.75, 2.75)	1.00 (0.95, 1.06)	0.93	1.04 (0.97, 1.10)	0.29
	Female	636	95	1.80 (0.83, 2.94)	1.08 (1.01, 1.16)	0.018	1.08 (1.01, 1.16)	0.034

^*Median (Q₁, Q₃)

^†Crude/unadjusted hazard ratios estimated for a 500-unit increase in aortic valve calcium score

^‡Propensity score adjusted hazard ratios estimated for a 500-unit increase in aortic valve calcium score

Propensity score included age, pre-TAVR peak aortic valve velocity, pre-TAVR calculated valve area, pre-TAVR stroke volume index, pre-TAVR LVEF, pacemaker implantation, LBBB, Charlson comorbidity index, STS predicted risk of surgical mortality, TAVR access type, valve type, procedure site and post-TAVR peri-valvular leak.

LBBB – Left bundle branch block; LVEF – Left ventricular ejection fraction; TAVR – Transcatheter aortic valve replacement; STS – Society for thoracic surgeons