Table 4.

Cox-proportional hazards regression model showing the impact of aortic valve calcium score density on long-term mortality (for the entire cohort, stratified by sex and year of TAVR procedure)

TAVR year	All patients	N	Deaths	Follow-Up (Years) *	cHR (95% CI) †	P-value	aHR (95% CI) ‡	P-value
All Patients (2010 – 2021)
	Overall	2400	689	2.25 (0.97, 4.06)	1.05 (1.02, 1.07)	0.001	1.06 (1.01, 1.11)	0.009
	Male	1419	413	2.15 (0.92, 4.02)	1.03 (0.99, 1.07)	0.099	1.03 (0.99, 1.08)	0.17
	Female	981	276	2.44 (1.10, 4.11)	1.06 (1.02, 1.10)	0.006	1.06 (1.01, 1.11)	0.011
2010 - 2016
	Overall	823	440	4.78 (2.39, 5.83)	1.05 (1.02, 1.09)	0.003	1.04 (0.98, 1.11)	0.16
	Male	475	258	4.79 (2.20, 5.76)	1.06 (1.01, 1.10)	0.015	1.04 (0.99, 1.10)	0.12
	Female	348	182	4.78 (2.71, 5.89)	1.05 (0.99, 1.11)	0.095	1.07 (1.00, 1.14)	0.055
2017 - 2021
	Overall	1577	249	1.69 (0.79, 2.84)	1.03 (0.98, 1.08)	0.27	1.08 (1.01, 1.15)	0.017
	Male	944	155	1.62 (0.75, 2.76)	0.98 (0.91, 1.05)	0.51	1.01 (0.93, 1.09)	0.90
	Female	633	94	1.80 (0.83, 2.94)	1.07 (1.01, 1.14)	0.034	1.07 (1.00, 1.14)	0.060

^*Median (Q₁,Q₃)

^†Crude/unadjusted hazard ratios estimated for a 100-unit increase in aortic valve calcium score density

^‡Propensity score adjusted hazard ratios estimated for a 100-unit increase in aortic valve calcium score density

Propensity score included age, pre-TAVR peak aortic valve velocity, pre-TAVR calculated valve area, pre-TAVR stroke volume index, pre-TAVR LVEF, pacemaker implantation, LBBB, Charlson comorbidity index, STS predicted risk of surgical mortality, TAVR access type, valve type, procedure site and post-TAVR peri-valvular leak.

LBBB – Left bundle branch block; LVEF – Left ventricular ejection fraction; TAVR – Transcatheter aortic valve replacement; STS – Society for thoracic surgeons