Table 1.
Baseline characteristics mouse experiment
| Characteristic | All | LBMI | WL | HC | P‐value |
|---|---|---|---|---|---|
| Donors | n = 12 | n = 5 | n = 4 | n = 3 | |
| Age (years) | 78.6 [71.4 to 83.2] | 75.9 [70.4 to 83.9] | 80.9 [70.7 to 88.1] | 79.4 [71.4 to 81.3] | 0.871 |
| Sex (male) | 3 (25.0) | 2 (40.0) | 1 (25.0) | 0 (0.0) | 0.727 |
| BMI (kg/m2) | 23.5 [19.6 to 24.7] | 19.4 [19.3 to 20.6] a | 23.7 [23.4 to 24.5] | 26.1 [24.6 to 26.6] a | 0.010 a |
| Weight difference (%/2 years) | −2.8 [−9.1 to −0.8] | −2.2 [−3.5 to 1.1] | −10.0 [−13.9 to −8.2] a | −0.7 [−1.1 to 2.0] a | 0.016 a |
| Mice | n = 41 | n = 17 | n = 14 | N = 10 | |
| Age (weeks) | 10 [10 to 10] | 10 [10 to 10] | 10 [9 to 11] | 10 [9 to 10] | 0.060 |
| Weight (g) | 37.3 [35.4 to 39.3] | 37.7 [36.7 to 40.3] a | 37.5 [36.5 to 39.5] | 35.1 [33.6 to 36.5] a | 0.030 a |
| Lean mass (g) | 31.4 [29.6 to 32.7] | 32.2 [31.1 to 33.7] a | 31.4 [30.2 to 32.1] | 29.7 [28.8 to 31.5] a | 0.025 a |
| Lean mass (%) | 82.8 [80.1 to 85.6] | 82.9 [79.7 to 87.3] | 81.9 [79.7 to83.6] | 85.4 [82.6 to 86.4] | 0.181 |
| Fat mass (g) | 4.4 [3.6 to 5.2] | 3.7 [3.2 to 5.0] | 4.8 [4.3 to 5.8] | 4.2 [3.6 to 5.6] | 0.118 |
| Fat mass (%) | 11.9 [9.8 to 13.4] | 9.9 [8.9 to 12.1] a | 12.7 [11.6 to 14.7] a | 12.0 [10.2 to 14.7] | 0.024 a |
BMI, body mass index; HC, mice that received faecal microbiota from human donors without low BMI or substantial weight loss; LBMI, mice that received faecal microbiota from human donors with low BMI; WL, mice that received faecal microbiota from human donors with substantial weight loss.
Data are depicted in median [interquartile range] or number (percentage). Differences among groups are tested with Kruskal–Wallis test (continuous variables) or Fisher's exact test (categorical variables).
a
Groups that differ based on pairwise testing with Bonferroni correction.