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. 2022 Jun 14;13(4):2188–2201. doi: 10.1002/jcsm.13002

Table 2.

Differences in body weight, fat and lean mass, and food intake in LBMI vs. HC and WL vs. HC

LBMI (n donors = 5; n mice = 17) vs. HC (n donors = 3; n mice = 10) WL (n donors = 4; n mice = 14) vs. HC (n donors = 3; n mice = 10)
B 95% CI P‐value B 95% CI P‐value
Overall body weight (g) −0.76 −2.16 to 0.65 0.257 −0.69 −2.15 to 0.76 0.310
Body weight (g) at Week 1 −0.87 −2.33 to 0.60 0.226 −0.77 −2.29 to 0.75 0.292
Body weight (g) at Week 2 −0.14 −1.61 to 1.33 0.839 −0.53 −2.05 to 0.99 0.466
Body weight (g) at Week 3 −1.26 −2.73 to 0.21 0.086 −0.78 −2.30 to 0.74 0.286
Lean mass (g) at Week 3 1.36 −0.24 to 2.96 0.089 0.98 −0.67 to 2.63 0.214
Lean mass (%) at Week 3 6.13 −0.53 to 12.78 0.067 3.73 −3.23 to 10.68 0.257
Fat mass (g) at Week 3 −1.42 −3.98 to 1.13 0.241 −1.24 −3.90 to 1.42 0.320
Fat mass (%) at Week 3 −3.78 −9.56 to 2.00 0.174 −3.24 −9.24 to 2.76 0.254
Overall food intake (g/g) 0.06 −0.07 to 0.19 0.316 0.05 −0.08 to 0.18 0.422
Food intake (g/g) at Week 1 −0.03 −0.18 to 0.13 0.735 0.02 −0.15 to 0.18 0.838
Food intake (g/g) at Week 2 0.11 −0.05 to 0.27 0.153 0.07 −0.10 to 0.23 0.407
Food intake (g/g) at Week 3 0.09 −0.07 to 0.25 0.235 0.06 −0.10 to 0.23 0.425

HC, mice that received faecal microbiota from human donors without low body mass index or substantial weight loss; LBMI, mice that received faecal microbiota from human donors with low body mass index; WL, mice that received faecal microbiota from human donors with substantial weight loss.

Data are depicted in regression estimate (B), 95% confidence interval (95% CI), and P‐values. The number of donors and corresponding mice per group are reported. Differences between groups were tested with linear mixed models. Models for outcomes on body weight, lean mass, and fat mass models were adjusted for baseline values. Random intercepts for donor ID were included in all models to adjust for dependency of same‐donor colonization. For outcomes on body weight, random intercepts for mouse ID were included as well to adjust for repeated measures.