Table 2.
LBMI (n donors = 5; n mice = 17) vs. HC (n donors = 3; n mice = 10) | WL (n donors = 4; n mice = 14) vs. HC (n donors = 3; n mice = 10) | |||||
---|---|---|---|---|---|---|
B | 95% CI | P‐value | B | 95% CI | P‐value | |
Overall body weight (g) | −0.76 | −2.16 to 0.65 | 0.257 | −0.69 | −2.15 to 0.76 | 0.310 |
Body weight (g) at Week 1 | −0.87 | −2.33 to 0.60 | 0.226 | −0.77 | −2.29 to 0.75 | 0.292 |
Body weight (g) at Week 2 | −0.14 | −1.61 to 1.33 | 0.839 | −0.53 | −2.05 to 0.99 | 0.466 |
Body weight (g) at Week 3 | −1.26 | −2.73 to 0.21 | 0.086 | −0.78 | −2.30 to 0.74 | 0.286 |
Lean mass (g) at Week 3 | 1.36 | −0.24 to 2.96 | 0.089 | 0.98 | −0.67 to 2.63 | 0.214 |
Lean mass (%) at Week 3 | 6.13 | −0.53 to 12.78 | 0.067 | 3.73 | −3.23 to 10.68 | 0.257 |
Fat mass (g) at Week 3 | −1.42 | −3.98 to 1.13 | 0.241 | −1.24 | −3.90 to 1.42 | 0.320 |
Fat mass (%) at Week 3 | −3.78 | −9.56 to 2.00 | 0.174 | −3.24 | −9.24 to 2.76 | 0.254 |
Overall food intake (g/g) | 0.06 | −0.07 to 0.19 | 0.316 | 0.05 | −0.08 to 0.18 | 0.422 |
Food intake (g/g) at Week 1 | −0.03 | −0.18 to 0.13 | 0.735 | 0.02 | −0.15 to 0.18 | 0.838 |
Food intake (g/g) at Week 2 | 0.11 | −0.05 to 0.27 | 0.153 | 0.07 | −0.10 to 0.23 | 0.407 |
Food intake (g/g) at Week 3 | 0.09 | −0.07 to 0.25 | 0.235 | 0.06 | −0.10 to 0.23 | 0.425 |
HC, mice that received faecal microbiota from human donors without low body mass index or substantial weight loss; LBMI, mice that received faecal microbiota from human donors with low body mass index; WL, mice that received faecal microbiota from human donors with substantial weight loss.
Data are depicted in regression estimate (B), 95% confidence interval (95% CI), and P‐values. The number of donors and corresponding mice per group are reported. Differences between groups were tested with linear mixed models. Models for outcomes on body weight, lean mass, and fat mass models were adjusted for baseline values. Random intercepts for donor ID were included in all models to adjust for dependency of same‐donor colonization. For outcomes on body weight, random intercepts for mouse ID were included as well to adjust for repeated measures.