Table 1.

Involvement of phosphatidylserine binding receptors or bridging molecules in efferocytosis, skeletal muscle development and repair, and in vitro myoblast fusion

Receptor or bridging molecule	Involvement in
	efferocytosis	embryonal myogenesis	skeletal muscle repair	in vitro myoblast fusion
Myoferlin	n.d.	Yes 80	Yes 80	Yes 80
Integrin β1	Yes 32	Yes 104	Yes 105	Yes, 105 no 106
Integrin β3	Yes 24	n.d.	Yes 106	Yes, 81 but has to be down‐regulated 82
Integrin β5	Yes 31	n.d.	n.d.	Yes 107
CD36	Yes 24 , 28	No effect 108	Both SCs and macrophages are affected 107	Yes 109
TG2	Yes 30	Yes 91	Yes 91	Crosslinking activity is not needed, 90 but the protein yes 91
TIM3	Yes 43	n.d.	n.d.	n.d.
TIM4	Yes 43	n.d.	n.d.	n.d.
MFG‐E8	Yes 29	n.d.	n.d.	Promotes myoblast differentiation and possibly fusion 88
Tsp‐1	Yes 24	No effect 110	Macrophage‐dependent effect 111	Promotes adhesion, 83 but inhibits fusion 84
Mer	Yes 34	Not expressed 10 ¤	Macrophage‐dependent effect 10	Not expressed 10
Axl (Gas6)	Yes 35	Yes 86 , 87	Yes 87	Promotes myoblast and myotube survival and growth 10
Tyro‐3	Yes 35	Not expressed 10	n.d.	Not expressed 10
Protein S	Yes 35 , 36	n.d.	n.d.	Secreted by myoblasts 112
CD91	Yes 37 , 38	n.d.	n.d.	n.d.
Calreticulin	Yes 37 , 39	n.d.	n.d.	Secreted by myoblasts 112
C1q	Yes 37 , 38	n.d.	Negative effect 113	n.d.
SCARF1	Yes 40	n.d.	n.d.	n.d.
MEGF10	Yes 41	Yes 114	Yes 115	Yes 116
BAI1	Yes 44	Yes 14	Yes 14	Yes 14
BAI3	Not involved	Yes 117	Yes 117	Yes 117 , 118
Gpr56	Yes 46	No effect 119	n.d.	Yes 119
Stabilin2	Yes 49 , 50	Yes 15	Yes 15	Yes 15 , 117
SR‐BI	Yes 9 , 51	No effect 9	Macrophage‐dependent effect 9	n.d.
CD300	Yes 52 , 53	n.d.	n.d.	n.d.
RAGE	Yes 54 , 55	Increased number of SCs 120	Yes 120	Myoblast differentiation, 121 fusion was n.d.
LOX‐1	Yes 56	n.d.	n.d.	n.d.
Annexins	Yes 122	No effect 123	Yes 123	Yes 78
Piezo	n.d.	n.d.	n.d.	Yes 124

n.d., not determined.