Table 1.
Protein (human) | Other names | Protein (yeast) | Function | Ub-related domains | Other domains | L | M | C | TM |
---|---|---|---|---|---|---|---|---|---|
Uba1 | Uba1p | Ubiquitin-activating enzyme | X | – | |||||
Ube2j1, Ube2j2 | Ubc6e | Ubc6p | Ubiquitin-conjugating enzyme | UBCc | X | X | TA | ||
Ube2g2 | Ubc7p | Ubiquitin-conjugating enzyme | UBCc | X | – | ||||
Hrd1 | Synoviolin | Hrd1p | Ubiquitin ligase | RING | VBMa | X | X | X | 6 |
TEB4 | March IV | Doa10p | Ubiquitin ligase | RING | X | X | X | 12 | |
gp78 | AMFR, RNF45 | Ubiquitin ligase | RING, CUEb, G2BR | VIMa | X | X | X | 6 | |
RNF5 | RMA1 | Ubiquitin ligase | RING | X | X | X | 2 | ||
RNF170 | Ubiquitin ligase | RING | X | X | X | 3 | |||
Trc8 | RNF138 | Ubiquitin ligase | RING | X | X | X | 8 | ||
RNF103 | Kf-1 | Ubiquitin ligase | RING | X | X | X | 4 | ||
RFP2 | Ubiquitin ligase | RING | B-box | X | X | X | T1 | ||
Fbx2 | Ubiquitin ligase | F-Box | X | – | |||||
Fbx6 | Ubiquitin ligase | F-Box | X | – | |||||
Parkin | PARK2 | Ubiquitin ligase | RING, UBL | IBR | X | – | |||
CHIP | Ubiquitin ligase | U-Box | TPR | X | – | ||||
UBE4a | Ufd2p | Ubiquitin ligase | U-Box | X | – | ||||
USP13 | Deubiquitinase | UBAb (2) | X | – | |||||
USP25 | Deubiquitinase | UIMb (2), UBAb | SIM | X | – | ||||
YOD1 | OTUD2 | Deubiquitinase | OTU, UBX | X | – | ||||
Ataxin-3 | Deubiquitinase | UIMb | Josephin, VBMa | X | – | ||||
OTUB1 | Deubiquitinase | OTU | X | – | |||||
VCIP135 | VCPIP | Deubiquitinase | OTU | X | – | ||||
HERP | Usa1p | Scaffolding | UBL | X | X | MA | |||
TMUB1 | Scaffolding | UBL | NES | X | X | X | 2 | ||
FAM8A1 | Ubiquitin-ligase cofactor | X | X | X | 3 | ||||
AUP1 | Cue1p | E2 recruitment, ubiquitin binding | CUEb, G2BR | X | X | MA |
Common and alternate mammalian ERAD-component names are given, along with yeast orthologs. Putative function within ERAD is shown, in addition to ubiquitin-related and other domains (numbers of domains are shown in parentheses). Cellular exposure to ER lumen (L), ER membrane (M) or cytoplasm (C) is indicated by ‘X’. Links with the ER membranes are listed under TM: numbers, polytopic TM domains; T1, type I; TA, tail-anchored; MA, membrane associated.
p97/VCP-binding domain.
Ubiquitin-binding domain.