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. 2022 Jun 27;11(8):828–840. doi: 10.1093/stcltm/szac041

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Non-dose-dependent effects of WJ-MSC EVs in BPD and PH. Similar reduction in (A) right ventricular systolic pressure, (B) RV/LV+S, and (C) percentage of muscularized vessels in 2-week-old hyperoxia (HYP) exposed rats treated with IT low dose (LD), medium dose (MD) and high dose (HD) WJ-MSC EV. IT WJ-MSC EV non-dose dependently (D) increased lung vascular density, (E) decreased mean linear intercept and (F) increased radial alveolar count. Data are presented as mean ± SEM; N = 6/group. *P < .05, room air (RA) placebo (PL) vs. HYP PL or HYP PL vs. HYP WJ-MSC EV LD, MD or HD.