Table 4.

SMCs and baseline factors affecting cognitive decline in NC & MCI participants

					95% Confidence Interval
	Fixed Terms in final model	Estimate	Std. Err.	p	Lower Bound	Upper Bound
Total Cohort NC + MCI	PRMQ Self (N = 369)
	PRMQ Self×Time (y)	–0.0076	0.006	0.195	–0.0191	0.0039
	MMSE at baseline	0.8260	0.027	< 0.001	0.7721	0.8798
	PRMQ Self	0.0050	0.005	0.344	–0.0054	0.0154
	Time (years)	0.0090	0.235	0.969	–0.4516	0.4697
	Education	0.0489	0.015	0.001	0.0190	0.7875
	Diagnosis (MCI)	–0.4073	0.102	< 0.001	–0.6078	–0.2069
	PRMQ Proxy (N = 333)
	PRMQ Proxy×Time (y)	–0.0207	0.005	< 0.001	–0.0303	–0.0111
	MMSE at baseline	0.8263	0.027	< 0.001	0.7730	0.8796
	PRMQ Proxy	0.0040	0.005	0.444	–0.0063	0.0143
	Time (years)	0.3556	0.152	0.019	0.0574	0.6539
	Education	0.0621	0.015	< 0.001	0.0324	0.0918
	Diagnosis (MCI)	–0.3636	0.119	0.002	–0.0597	–0.1305
Amyloid + Subgroup NC + MCI	PRMQ Self (N = 21)
	PRMQ Self×Time (y)	–0.0538	0.022	0.015	–0.0974	–0.0103
	MMSE at baseline	0.8544	0.155	< 0.001	0.5501	1.159
	PRMQ Self	0.0105	0.026	0.691	–0.0413	0.0623
	Time (years)	1.7951	0.9659	0.063	–0.0981	3.6883
	Diagnosis (MCI)	–0.5735	0.4768	0.229	–1.5081	0.3611
	PRMQ Proxy (N = 29)
	PRMQ Proxy×Time (y)	–0.0407	0.019	0.035	–0.0786	–0.0030
	MMSE at baseline	0.9721	0.107	< 0.001	0.7623	1.1812
	PRMQ Proxy	0.0180	0.021	0.396	–0.0236	0.0597
	Time (years)	0.8930	0.4748	0.232	–0.5727	2.3588
	Diagnosis (MCI)	–0.3290	0.499	0.510	–1.3071	0.6490

The above fixed effects remained in the final model following optimization with backward selection. Random effects included a random intercept for each subject and a random slope for time in years, for which model statistics are not shown. MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; NC, normal cognition; PRMQ, Prospective Retrospective Memory Questionnaire.