Table 3:
Pharmacokinetics of Panitumumab-IRDye800CW
| Dose cohort | Dose range (mg/kg) | % of therapeutic dosea | Total number of patients | Half-life, average (h) (SD) |
|---|---|---|---|---|
|
| ||||
| <0.5 mg/kg | 0.06–0.49 | 1.0–8.2% | 8 | 14.5 (4.12) |
| 0.5–1.0 mg/kg | 0.52–0.97 | 8.6–16.1% | 32 | 20.9 (5.52) |
| 1.0–1.5 mg/kg | 1.05–1.48 | 17.5–24.7% | 13 | 24.8 (6.9) |
| 1.5–2.0 mg/kg | 1.52–1.98 | 25.3–33.0% | 10 | 35.7 (11.4) |
| 2.0–3.0 mg/kg | 2.09–2.84 | 34.8–47.3% | 10 | 33.3 (5.4) |
Therapeutic dose = 6 mg/kg.