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. 2022 Aug 23;19(8):e1004074. doi: 10.1371/journal.pmed.1004074

Table 2. Characteristics of included studies.

Author Title Country ACS Tocolytics MgSO4 Antibiotics Designs Sample size Participants
Tucker Edmonds 2015 [41] The influence of resuscitation preferences on obstetrical management of periviable deliveries United States of America Survey 295 Obstetrician gynaecologists
Vargas-Origel 2000 [55] ACS. Its use and the obstetrician attitudes. Mexico Prospective observational with survey 48 Obstetricians
Buchanan 2004 [57] Preterm prelabour rupture of the membranes: a survey of current practice Australia Questionnaire 731 Obstetricians
Bousleiman 2015 [42] Use and attitudes of obstetricians toward 3 high-risk interventions in MFMU Network hospitals United States of America Survey 329 Obstetricians
Battarbee 2020 [43] Management of diabetic women with threatened preterm birth: a survey of Maternal-Fetal Medicine providers United States of America Survey 159 MFM providers
Chan 2006 [69] Staff views on the management of the extremely preterm infant United Kingdom Questionnaire 69 Obstetricians, neonatologists, midwives, and neonatal nurses
Capeless 1987 [44] Management of preterm premature rupture of membranes: lack of a national consensus United States of America and Canada Questionnaire 285 Obstetricians
Bain 2013 [58] Implementation of a clinical practice guideline for antenatal magnesium sulphate for neuroprotection in Australia and New Zealand Australia and New Zealand Survey 25 Obstetricians, trainee medical officers, midwives
Aghajafari 2002 [52] Multiple versus single courses of ACS for preterm birth: a pilot study Canada Randomised controlled trial with questionnaire 12 Women
Hueston 1997 [45] Variations between family physicians and obstetricians in the evaluation and treatment of preterm labour United States of America Questionnaire 321 Obstetrician gynaecologists and family physicians
Smith 2011 [73] Practices for predicting and preventing preterm birth in Ireland: a national survey Ireland Questionnaire 66 Obstetrician gynaecologists
Battarbee 2019 [46] Practice Variation in Antenatal Steroid Administration for Anticipated Late Preterm Birth: A Physician Survey United States of America Survey 193 Obstetricians
Danerek 2012 [74] Attitudes of Swedish midwives towards management of extremely preterm labour and birth Sweden Questionnaire 259 Midwives
Hutton 1989 [64] New Zealand obstetricians’ management of hypertension in pregnancy. A questionnaire survey New Zealand Questionnaire 65 Obstetricians
Erickson 2001 [47] Obstetrician-gynaecologists’ knowledge and training about ACS United States of America Questionnaire 487 Obstetricians
Cook 2004 [59] Survey of the management of preterm labour in Australia and New Zealand in 2002 Australia and New Zealand Questionnaire 813 Obstetrician gynaecologists
Gatman 2020 [60] Survey on use of antenatal magnesium sulphate for fetal neuroprotection prior to preterm birth in Australia and New Zealand: Ongoing barriers and enablers Australia and New Zealand Questionnaire 24 Obstetrician, midwives, neonatologists
Glass 2005 [48] Opportunities to reduce overuse of antibiotics for perinatal group B streptococcal disease prevention and management of preterm premature rupture of membranes United States of America Questionnaire 519 Obstetrician gynaecologists
Chollat 2017 [75] Antenatal magnesium sulphate administration for fetal neuroprotection: a French national survey France Online and phone survey 138 Obstetricians, anaesthetists, neonatologists
Aleman 2013 [56] Use of ACS for preterm birth in Latin America: providers knowledge, attitudes, and practices Ecuador, El Salvador, Mexico and Uruguay Questionnaire 353 Physicians, midwives, nurse, in some cases medical students
Baker 2015 [53] Current practices in the prediction and prevention of preterm birth in patients with higher-order multiple gestations Canada Survey 81 MFM specialists
Saengwaree 2005 [77] Changing physician’s practice on ACS in preterm birth Thailand Medical records review and questionnaire 39 (questionnaire only) Obstetricians
Wilson 2002 [70] The Leeds University Maternity Audit Project United Kingdom Case note audit and interview 88 taped interviews Obstetricians, unit manager, paediatrician, midwife
Hong 2017 [65] Resident Quality Improvement Project: Antenatal Magnesium Sulfate Protocol for Fetal Neuroprotection in Preterm Births Singapore Prospective study with audit and survey 42 Staff members of the hospital
Hui 2007 [54] Preterm Labour and Birth: A Survey of Clinical Practice Regarding Use of Tocolytics, ACS, and Progesterone Canada Survey 2,821 Obstetricians
Kenyon 2010 [71] Has publication of the results of the ORACLE Children Study changed practice in the UK? United Kingdom Questionnaire 324 Obstetricians
McGoldrick 2017 [61] Investigating antenatal corticosteroid clinical guideline practice at an organisational level Australia and New Zealand Questionnaire 40 Clinical managers at 27 secondary and 25 tertiary maternity hospitals
TuckerEdmonds 2015 [50] A national survey of obstetricians’ attitudes toward and practice of periviable intervention United States of America Questionnaire 310 Obstetrician gynaecologists, MFM specialists
Rousseau 2020 [76] Do obstetricians apply the national guidelines? A vignette-based study assessing practices for the prevention of preterm birth France Survey (structured and open-ended questions) 423 Obstetricians
Tucker Edmonds 2015 [49] Comparing obstetricians’ and neonatologists’ approaches to periviable counselling United States of America Exploratory simulation study 31 Obstetricians and neonatologists
Liu 2015 [22] ACS for management of preterm birth: a multi-country analysis of health system bottlenecks and potential solutions Afghanistan, Cameroon, Democratic Republic of Congo, Kenya, Malawi, Nigeria, Uganda, Bangladesh, India, Nepal, Pakistan, and Vietnam Maternal-newborn bottleneck analysis through workshop and survey Not specified Health providers and policymakers
Kankaria 2021 [78] Readiness to Provide Antenatal Corticosteroids for Threatened Preterm Birth in Public Health Facilities in Northern India India Cross-sectional through facility assessment, semistructured questionnaire, report summary 107 Health providers and women
McGoldrick 2016 [62] Consumers attitudes and beliefs towards the receipt of ACS and use of clinical practice guidelines Australia and New Zealand Qualitative interviews and open-ended questionnaire 24 Women
Hsieh 2006 [67] The lived experience of first-time expectant fathers whose spouses are tocolyzed in hospital Taiwan Qualitative interviews 6 Partners of women
Greensides 2018 [79] ACS for women at risk of imminent preterm birth in 7 sub-Saharan African countries: a policy and implementation landscape analysis Democratic Republic of the Congo, Ethiopia, Malawi, Nigeria, Sierra Leone, Tanzania, and Uganda Document reviews and qualitative interviews 12 Senior-level ministry of health representative, and organisations working closely with Ministry of Health
Bain 2015 [23] Barriers and enablers to implementing antenatal magnesium sulphate for fetal neuroprotection guidelines: a study using the theoretical domains framework Australia Qualitative interviews 45 Obstetricians, midwives, neonatologists
Antony 2019 [80] Qualitative assessment of knowledge transfer regarding preterm birth in Malawi following the implementation of targeted health messages over 3 years Malawi Focus group discussions 70 Nurse midwives, CHWs, nurses, matrons, clinic land medical officers, medical and dental assistants, health surveillance assistants
Kaplan 2016 [40] Reliable implementation of evidence: a qualitative study of antenatal corticosteroid administration in Ohio hospitals United States of America Focus group discussions, qualitative interviews 97 Obstetricians, physician trainees, nurse midwives, nurses
Levison 2014 [81] Qualitative assessment of attitudes and knowledge on preterm birth in Malawi and within country framework of care Malawi Focus group discussions, incidence narrative, qualitative interviews 33 participants on focus groups, unclear how many were interviewed Women, partners, community health workers, nurse midwife/matrons, clinical officers (physician)
Leviton 1995 [24] An exploration of opinion and practice patterns affecting low use of ACS United States of America Qualitative interviews and focus group discussions 8 interview participants; 4 focus groups (total not stated but 8–15 participants on each group) Obstetricians and neonatologists
McGoldrick 2016 [63] Identifying the barriers and enablers in the implementation of the New Zealand and Australian Antenatal Corticosteroid Clinical Practice Guidelines Australia and New Zealand Qualitative interviews or open-ended questionnaire 73 Obstetricians, midwives, neonatologists, paediatricians
Hu 2006 [66] Study of stress and coping behaviours in families of hospitalized pregnant woman undergoing tocolysis Taiwan Qualitative interviews Unclear Women’s partners
Kalb 1993 [51] Women’s experiences using terbutaline pump therapy for the management of preterm labour United States of America Qualitative interviews 12 Women
Smith 2016 [68] Providing ACS for preterm birth: a quality improvement initiative in Cambodia and the Philippines Cambodia and Philippines Pre- and post-intervention design with monthly audit and feedback sessions (written data) Not specified Maternity care staffs that participate in audit process
Burhouse 2017 [72] Preventing cerebral palsy in preterm labour: a multiorganisational quality improvement approach to the adoption and spread of magnesium sulphate for neuroprotection United Kingdom Quality improvement study with qualitative evaluation (focus groups, surveys, quantitative data capture) Not specified Medical staffs: only midwives mentioned
Teela 2015 [82] Magnesium sulphate for fetal neuroprotection: benefits and challenges of a systematic knowledge translation project in Canada Canada Focus group discussions, site visits, survey 188 survey respondents Physicians, nurses, midwives, residents, students, pharmacist, administrators

CHW, community health worker; MFM, maternal-fetal medicine.