. 2022 Aug 23;34(11):2751–2759. doi: 10.1007/s40520-022-02223-8

Table 4.

Parsimonious logistic regression models, adjusted for demographics and removing covariates near to p = 1 in fully adjusted models, showing interrelated progression of white matter hyperintensities with cerebral microbleeds and enlarged basal ganglia-perivascular spaces. Lacunes progression is independent to the progression of the other cerebral small vessel disease biomarkers (numbers in cells correspond to odds ratios with 95% confidence intervals)

Independent variables	Dependent variables
Independent variables	WMH progression^b	CMB progression^c	Lacunes progression^d	Enlarged BG-PVS progression^e
WMH progression	.	2.91 (1.13–7.49)^a	3.34 (0.78–14.2)	4.45 (2.21–8.96)^a
CMB progression	2.76 (1.07–7.11)^a	.	3.79 (0.83–17.4)	1.04 (0.37–2.91)
Lacunes progression	2.73 (0.69–10.8)	3.29 (0.75–14.5)	.	2.34 (0.63–8.64)
Enlarged BG-PVS progression	4.37 (2.16–8.83)^a	1.02 (0.37–2.77)	2.25 (0.58–8.66)	.

WMH white matter hyperintensities, CMB cerebral microbleeds, BG-PVS basal ganglia-perivascular spaces

^aStatistical significant result

^bAdjusted for age, sex, body mass index, physical activity, diet, and total cholesterol blood levels

^cAdjusted for age, sex, physical activity, blood pressure, and fasting glucose

^dAdjusted for age, sex, and diet

^eAdjusted for age, sex, body mass index, physical activity, blood pressure, and total cholesterol blood levels