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. 2021 Jun 22;20(9):1499–1507. doi: 10.1158/1535-7163.MCT-21-0221

Figure 4.

Figure 4. Pharmacokinetic/pharmacodynamic analysis of TPX-0131 in the EML4-ALK G1202R/L1196M xenograft model. Bar graph quantitates the degree of phosphorylation (Tyr1282/12833) modulation of ALK as a function of dose. The TPX-0131 unbound exposure is shown as red squares. Higher TPX-0131 exposure correlates with lower levels of ALK phosphorylation. Primary data can be found in the supplemental information (Supplementary Fig. S3).

Pharmacokinetic/pharmacodynamic analysis of TPX-0131 in the EML4-ALK G1202R/L1196M xenograft model. Bar graph quantitates the degree of phosphorylation (Tyr1282/12833) modulation of ALK as a function of dose. The TPX-0131 unbound exposure is shown as red squares. Higher TPX-0131 exposure correlates with lower levels of ALK phosphorylation. Primary data can be found in the supplemental information (Supplementary Fig. S3).