Table 1.
Proportional hazard ratios for fatty acids in serum cholesteryl esters in relation to CVD and total mortality
| Fatty acid and estimated desaturase activities | Scrum proportion* | Cardiovascular disease mortality† (n = 461 events) | Total mortality† (n = 1012 events) | ||
|---|---|---|---|---|---|
| Crude | Adjusted‡ | Crude | Adjusted‡ | ||
| Myristic acid (14:0) | 1.1 ± 0.3 | 1.16 (1.06, 1.27) | 1.12 (1.02, 1.23) | 1.09 (1.03, 1.16) | 1.06 (0.99, 1.13) |
| Palmitic acid (16:0) | 11.7 ± 0.99 | 1.25 (1.14, 1.37) | 1.15 (1.04, 1.26) | 1.16 (1.09, 1.24) | 1.09 (1.02, 1.17) |
| Palmitoleic acid (16:1) | 3.5 (3.0–4.4) | 1.32 (1.21, 1.44) | 1.18 (1.07, 1.30) | 1.28 (1.21, 1.36) | 1.19 (1.11, 1.27) |
| Stearic acid (18:0) | 1.1 (0.97–1.3) | 1.07 (0.97, 1.17) | 1.04 (0.94, 1.15) | 1.01 (0.95, 1.08) | 0.98 (0.91, 1.04) |
| Oleic acid (18:1) | 19.4 ± 2.7 | 1.29 (1.18, 1.41) | 1.18 (1.07, 1.30) | 1.25 (1.18, 1 33) | 1.17 (1.10, 1.25) |
| Linoleic acid (18:2n–6) | 53.9 ± 5.2 | 0.76 (0.70, 0.83) | 0.85 (0.78, 0.94) | 0.80 (0.76, 0.85) | 0.87 (0.81, 0.93) |
| γ-Linolenic acid (18:3n–6) | 0.71 ± 0.30 | 1.15 (1.05, 1.27) | 1.09 (0.98, 1.21) | 1.08 (1.01, 1.15) | 1.04 (0.97, 1.11) |
| α-Linolenic acid (18:3n–3) | 0.66 ± 0.16 | 1.08 (0.99, 1.18) | 1.10 (1.0, 1.21) | 1.03 (0.97, 1.09) | 1.03 (0.97, 1.10) |
| Dihomo-γ-linolenic acid (20:3n–6) | 0.57 ± 0.13 | 1.16 (1.07, 1.27) | 1.06 (0.96, 1.18) | 1.07 (1.01, 1.14) | 1.0 (0.94, 1.08) |
| Arachidonic acid (20:4n–6) | 4.8 ± 0.93 | 1.00 (0.92, 1.10) | 0.95 (0.86, 1.05) | 0.98 (0.92, 1.04) | 0.96 (0.90, 1.02) |
| Eicosapentaenoic acid (20:5n–3) | 1.3 (0.9–1.6) | 1.07 (0.98, 1.17) | 0.99 (0.90, 1.09) | 1.04 (0.98, 1.11) | 1.0 (0.94, 1.08) |
| Docosahexaenoic acid (22:6n–3) | 0.68 (0.56–0.81) | 0.97 (0.89, 1.07) | 0.92 (0.84, 1.02) | 0.96 (0.90, 1.02) | 0.95 (0.89, 1.02) |
| SCD (16:1/16:0) | 0.30 (0.26–0.37) | 1.27 (1.16, 1.39) | 1.15 (1.04, 1.27) | 1.26 (1.18, 1.34) | 1.18 (1.10, 1.26) |
| D6D (18:3n–6 /18:2n–6) | 0.012 (0.009–0.017) | 1.20 (1.10, 1.32) | 1.12 (1.0, 1.24) | 1.12 (1.06, 1.19) | 1.07 (1.0, 1.14) |
| D5D (20:4n–6/20:3n–6) | 8.6 ± 2.0 | 0.84 (0.76, 0.93) | 0.88 (0.80, 0.98) | 0.92 (0.86, 0.98) | 0.96 (0.89, 1.02) |
CVD, cardiovascular disease; FAs, fatty acids; SCD, steroyl-CoA-desaturated; D6D, Δ6-desaturase; D5D, Δ5-desaturase.
*
Values are means ± SD or means (interquartile ranges).
†
Values are hazard ratios (95% confidence intervals).
‡
The adjusted model included total-C, body mass index, smoking, physical activity, and hypertension.
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