TABLE A3.

Bias and reproducibility of longitudinal measurements over 4 weeks

ADCn (10−3 mm2/s)	${\mu }_{\mathrm{L}}$	${\stackrel{\sim }{\mu }}_{\mathrm{L}}$	${\sigma }_{\mathrm{L}}$	${\mathcal{R}}_{\mathrm{L}}$	${\mathcal{B}}_{\mathrm{L}}$ (%)	COVL (%)
1.127	1.114	1.115	0.006	0.012	−1.2	0.5
0.843	0.845	0.846	0.009	0.020	0.2	1.1
0.607	0.603	0.601	0.008	0.018	−0.7	1.3
0.403	0.399	0.400	0.006	0.013	−1.0	1.5
0.248	0.244	0.245	0.006	0.013	−1.6	2.5
0.128	0.139	0.140	0.003	0.008	8.6	2.2

T1n (ms)
1879.0	1895.9	1906.4	44.7	150.4	0.9	2.4
1432.0	1385.5	1396.7	28.9	93.6	−3.2	2.1
1027.0	1022.4	1025.1	17.2	45.2	−0.4	1.7
751.3	750.5	752.6	15.7	47.2	−0.1	2.1
527.0	525.7	527.7	11.4	32.9	−0.2	2.2
384.1	362.8	363.4	10.7	31.5	−5.5	2.9

T2n (ms)
258.4	259.4	259.9	4.0	12.6	0.4	1.5
186.1	190.2	190.3	1.7	5.2	2.2	0.9
137.0	133.1	133.0	1.7	5.8	−2.8	1.3
89.5	94.2	94.4	0.8	2.3	5.3	0.8
62.8	67.5	67.5	0.5	1.3	7.5	0.7
43.8	47.4	47.6	0.5	1.2	8.2	1.1

Note: ADC_n/T1_n/T2_n, nominal apparent diffusion coefficient (ADC)/T1/T2; ${\mu }_{\mathrm{L}}$/${\stackrel{\sim }{\mu }}_{\mathrm{L}}$/${\sigma }_{\mathrm{L}}$/${\mathcal{R}}_{\mathrm{L}}$, mean/median/standard deviation/range of longitudinal measurements (in units of their respective quantitative magnetic resonance imaging (qMRI) biomarker); ${\mathcal{B}}_{\mathrm{L}}$/COV_L, bias and coefficient of variation of longitudinal measurements.