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. Author manuscript; available in PMC: 2022 Aug 23.
Published in final edited form as: Science. 2021 Apr 22;372(6543):725–729. doi: 10.1126/science.abg2365

Table 3. Sensitivity analyses of the impact of maternal and paternal cumulative radiation dose modeling on association with DNMs.

All models are adjusted for sequencing batch, maternal and paternal age, and maternal and paternal smoking status. Additional analyses by dose categories are in table S6.

 Estimate  95% CI P-value
Cumulative radiation dose (/mGy)
 Maternal dose −0.02 −0.04, 0.007 0.17
 Paternal dose −0.0007 −0.003, 0.002 0.56
Cumulative radiation dose truncated at 1,000 (/mGy)
 Maternal dose −0.02 −0.04, 0.009 0.21
 Paternal dose −0.003 −0.008, 0.001 0.17
Cumulative log radiation dose (/ln(1+mGy))
 Maternal dose −0.87 −2.12, 0.39 0.18
 Paternal dose −0.37 −1.07, 0.33 0.30