Skip to main content
. 2022 Aug 17;42(33):6313–6324. doi: 10.1523/JNEUROSCI.0641-22.2022

Figure 2.

Figure 2.

CB2R agonists had no analgesic effect in mice. A, HU-308 did not reduce VMR to CRD. B, HU-308 did not alter colonic afferent nerve mechanosensitivity to probing (1 μm: F(3,24) = 0.0908, p = 0.9644, 10 μm: F(3,28) = 0.1098, p = 0.9537, one-way repeated-measures ANOVA with Bonferroni test, N = 5 or 6 mice for each). C, Similarly, JWH-133 did not alter colonic mechanosensitivity to probing (1 μm: F(3,24) = 1.617, p = 0.2117, 10 μm: F(3,27) = 0.3189, p = 0.8116, one-way repeated-measures ANOVA with Bonferroni test, N = 5 or 6 mice for each). D, Incubation with HU-308 (100 nm and 1 μm) did not significantly alter excitability of DRG neurons (100 nm: p > 0.9999, 1 μm: p > 0.9999), but 10 μm HU-308 decreased the rheobase (i.e., increased excitability; p = 0.0021). E, JWH-133 did not change rheobase of DRG neurons (100 nm: p > 0.9999, 1 μm: p > 0.9999, 10 μm: p = 0.4666). **p < 0.01.