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Combination of CB2R and MOR agonists had no effect on nociception. A, A combination of HU-308 (1 μm) and DAMGO (1 nm) did not reduce colonic mechanosensitivity (p = 0.7043), or DRG neuron excitability (B, p = 0.4098). C, Similarly, combining JWH-133 (1 μm) and DAMGO (1 nm) had no effect on colonic mechanosensitivity (p = 0.5923), nor DRG neuron excitability (D, p = 0.8424).
