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. 2022 Aug 17;42(33):6313–6324. doi: 10.1523/JNEUROSCI.0641-22.2022

Figure 5.

Figure 5.

The synergy of CB1R and MOR was mediated via NO. A, The inhibitory effect of the mix of HU-210 and DAMGO on DRG neuron excitability was reversed by ODQ (p = 0.0155). B, The inhibitory effect of the mix on DRG neuron excitability was attenuated by preincubation with NPL (p = 0.0012). The effect of L-NIL was not significant (p = 0.1231). C, In colonic afferent nerve recordings, the inhibitory effect of the mix was reduced by NPL (p = 0.0003) but not L-NIL (p = 0.9695). *p < 0.05. **p < 0.01. ***p < 0.001.