Figure 11.

Duplication of the Dp3Tyb region of mouse chromosome 21 orthologous with Hsa21 is not sufficient to decrease Aβ biochemical aggregation in the cortex of the App^NL-F/NL-F model at 3 months of age. Total cortical proteins of 3-month-old mice were prepared for MS analysis and Aβ abundance analyzed in the FA-soluble fraction by MSD assay (6E10). No difference in the abundance of FA-soluble (A) Aβ₃₈ (F_(1,21) = 1.001, p = 0.328), (B) Aβ₄₀ (F_(1,21) = 0.032 p = 0.860), or (C) Aβ₄₂ (F_(1,21) = 0.306, p = 0.443) was detected. App^NL-F/NL-F (female n = 8, male n = 5), Dp3Tyb;App^NL-F/NL-F (female n = 4, male n = 9). For clarity: Dp3, Dp3Tyb. Error bars indicate SEM. Data points represent independent mice.