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. 2022 Aug 17;42(33):6453–6468. doi: 10.1523/JNEUROSCI.0521-22.2022

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Figure 4. — Duplication of the Dp3Tyb region of mouse chromosome 21 orthologous with Hsa21 is sufficient to decrease Aβ accumulation in the App^NL-F/NL-F model. A–C, Aβ deposition (82E1) in the cortex was quantified at 8 months of age in male and female mice by manual plaque counting. A, Significantly fewer Aβ deposits were observed in the cortex of Dp3Tyb;App^NL-F/NL-F compared with App^NL-F/NL-F controls (F_(1,18) = 12.359, p = 0.002). App^NL-F/NL-F female n = 2, male n = 7; Dp3Tyb;App^NL-F/NL-F female n = 9, male n = 5. No amyloid deposits were observed in n = 4 WT controls. B, A nonsignificant trend for reduced Aβ deposits in the cortex was observed in Dp(10)2Yey;App^NL-F/NL-F compared with App^NL-F/NL-F controls (F_(1,11) = 12.359, p = 0.077). App^NL-F/NL-F female n = 4, male n = 3; Dp(10)2Yey;App^NL-F/NL-F female n = 6, male n = 2. No Aβ deposits were observed in WT n = 6 and Dp(10)2Yey n = 3 controls. C, No difference in Aβ deposits was observed in the cortex of Dp(17)3Yey;App^NL-F/NL-F compared with App^NL-F/NL-F controls (F_(1,18) = 0.021, p = 0.885). App^NL-F/NL-F female n = 6, male n = 4; Dp(17)3Yey App^NL-F/NL-F female n = 6, male n = 6. No Aβ deposits were observed in WT n = 6 and Dp(17)3Yey n = 6 controls. For clarity: Dp3, Dp3Tyb; Dp10, Dp(10)2Yey; Dp17, Dp(17)3Yey. Error bars indicate SEM, **p < 0.01. Data points represent independent mice.