Figure 9.
An additional copy of the Dp3Tyb region does not alter the abundance of mouse Aβ in the young cortex. Total cortical proteins were homogenized in TBS buffer, from mice of 3 months of age, and Aβ abundance was analyzed by MSD assay (4G8). An additional copy of the Dp3Tyb region did not alter the abundance of (A) Aβ40 (F(1,14) = 0.693, p = 0.419) or (B) Aβ42 (F(1,7) = 0.410, p = 0.718). WT (female n = 5, male n = 11), Dp3Tyb (female n = 7, male n = 12). Aβ40 (WT n = 4 and Dp3Tyb n = 5) and Aβ42 (WT n = 8 and Dp3Tyb n = 8) were below the limit of detection. Error bars indicate SEM. Data points represent independent mice. For clarity: Dp3, Dp3Tyb.