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. 2022 Aug 24;8(8):e10390. doi: 10.1016/j.heliyon.2022.e10390

Figure 4.

Figure 4

Protein network interaction diagram for Rhomboid protease (ROM7). ROM7 possesses serine-type endopeptidase activity, which activates its serine nucleophile by a proton and performs hydrolysis of internal, alpha-peptide bonds in a polypeptide chain (Neafsey et al., 2013). This protein has shown putative interactions with ROM8 and ROM9. The Plasmodium rhomboid proteases are involved in most enzymatic events during the invasive stages of the malaria lifecycle. The invasion of Plasmodium depends on the parasite transmembrane adhesins and these adhesins have to be processed by cleavage to be activated by PfROMs such as PfROM1, PfROM4 PfROM7, etc (Baker et al., 2006). Interaction network created using cytoscape 3.8.1. Legend: ROM = Rhomboid protease, MAL8P1.45 = Uncharacterized protein.