Skip to main content
. 2022 Aug 24;8(8):e10390. doi: 10.1016/j.heliyon.2022.e10390

Figure 7.

Figure 7

Illustration of “spectrinase activity” of plasmepsin II (PDB ID: 1SME) and falcipain of the malarial parasite on the human Erythroid Spectrin molecule (PDB ID:1S35). The spectrin linker region was extracted using PyMol (Schrödinger, Inc.), where it was prepared as a ligand and docked onto the active site of Plasmepsin II chain B using PyRx software. Relative free binding energies of the interaction between Plasmepsin II and spectrin indicated a positive interaction between the two molecules indicative of the role of plasmepsin II in spectrin cleavages into short peptides.