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. 2022 Aug 24;44(6):2701–2720. doi: 10.1007/s11357-022-00645-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Profiling-relevant mechanisms of TPE using selected 72 proteins. A Top 30 KEGG pathways. B Heat map with designations of the key functions of the groups of proteins. C The protein–protein interaction (PPI) network analysis of the canonical signaling pathways identifies TLR4 as the crosstalk node. D The PPI network analysis of the pathways in cancer identifies six designated nodal points of their interaction. E TLR4 gene expression levels in 349 young vs. old individuals (120.5 vs. 162.9, *p < 0.05). N^young = 181, N.^old = 168