Fig. 4.

Age and dementia–specific blood proteome clustering and reduction of blood TDP43 by TPE. A Distinct UMAP clustering of the 72 proteins that differ between Y and O, for the six age and disease groups showing that the population of the R0 is close to the old group. However, the R last cluster is closer to the middle-aged group. B Circulating TDP43 levels are higher in old than in young individuals (12,024 ± 399 vs. 7732 ± 346.8). Values are mean picograms/milliliters ± SEM. C TDP43 levels diminished right after TPE (R1: 0.99 ± 0.01 vs. 0.66 ± 0.03, R2: 0.82 ± 0.04 vs. 0.58 ± 0.04) and remained significantly low for 1 month until the next round (0.99 ± 0.01 vs. 0.82 ± 0.04). **p < 0.01, ***p < 0.001