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. 2022 Aug 22;4(8):1071–1083. doi: 10.1038/s42255-022-00617-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–f, Body weight (a), cumulative food intake (b), plasma glucose (c), change in blood glucose (d) and glucose tolerance (e,f) in 6-week-old obese db/db mice treated for 4 days at a dose of 50 nmol kg⁻¹ per day. Sample sizes for treatment with Vhcl, GLP-1RA, tesaglitazar or GLP-1RA/tesaglitazar are n = 6/7/6/7 (a,c,d) and n = 6/7/6/6 (e,f). Cumulative food intake was assessed per cage in n = 4/4/4/4 cages containing n = 6/7/6/7 mice (b). Data in a, b and e have been analysed by two-way ANOVA with Bonferroni post hoc comparison for individual time points. Data in c, d and f have been analysed by one-way ANOVA using the Bonferroni’s multiple comparison test. Data represent means ± s.e.m.; asterisks indicate *P < 0.05, **P < 0.01, ***P < 0.001. Black asterisks indicate comparison to Vhcl, red asterisks indicate comparison to GLP-1RA, blue asterisks indicate comparison to tesaglitazar. Exact P values for treatment effects are: a, P = 0.0353 (red asterisk), P = 0.0078 (black asterisks) and P = 0.0031 (blue asterisks); b, P = 0.0112 (red asterisk), P = 0.0007 (black asterisks) and P = 0.0002 (blue asterisks); c, P = 0.0062 (red asterisks) and P = 0.0025 (blue asterisks); d, P = 0.0409 (black asterisk), P = 0.0027 (red asterisks) and P = 0.0032 (blue asterisks); e, P = 0.0165 (red asterisk), P = 0.0009 (black asterisks) and P = 0.0002 (blue asterisks); f, P = 0.0075. For exact P values at individual time points (a,b,e), see the data source file.

Source data