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. 2022 Aug 22;4(8):1071–1083. doi: 10.1038/s42255-022-00617-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Chemical structures of the GLP-1RA (a) and the GLP-1RA/Tesaglitazar conjugate (b). Pharmacokinetic analysis of GLP-1RA and GLP-1RA/Tesaglitazar in 25–30-week-old male C57BL6/J mice (n = 4/4 mice) and 8–10-week-old male Sprague Dawley rats (n = 4/4 rats) (c). Abbreviations indicate half-life (T_1/2), maximum plasma concentration (C_max), time for maximal plasma concentration (T_max) and area under the curve from zero to last valid measurable concentration-timepoint (AUC_0-t). N/D not determinable. Data represent means ± SEM.

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