. 2022 Aug 12;31:101311. doi: 10.1016/j.bbrep.2022.101311

Table 3.

Seven different derivatives of the lead compound were tested to study the effect of different functional groups in the core structure..

Code	R	R′	R’’	IC₅₀ (μM)
PMD0033	2-Nitro	-COOH	H	63
PMD0022	3,4-Dihydroxy	-COOH	H	>200
PMD0026	4-N-(CH₃)₂	-COOH	H	>500

Code	R	R′	R’’	IC₅₀ (μM)
PMD0024		-COOH	CH₃	8.6
PMD0023		3,4-Dichloro	CH₃	>200