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. Author manuscript; available in PMC: 2023 Aug 22.
Published in final edited form as: Dev Cell. 2022 Jul 31;57(16):1995–2008.e5. doi: 10.1016/j.devcel.2022.07.007

Figure 1: Timing of XCI determines lineage-specific XCI ratio probability.

Figure 1:

A, Schematic representing completed XCI before germ layer specification. Each germ layer inherits the same randomly determined XCI ratio set prior to germ layer lineage specification. The probability distribution of XCI is determined by the number of cells present during inactivation. B, Schematic representing completed XCI after germ layer specification. The XCI ratio for each germ layer is set independent of one another, together along with variation in cell numbers fated for each germ layer results in variable XCI ratios across the germ layer lineages.