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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Clin Pharmacol Ther. 2022 May 22;112(3):653–664. doi: 10.1002/cpt.2630

Figure 2: Probenecid treatment alters the plasma metabolome.

Figure 2:

A) Probenecid levels in the plasma were significantly elevated 5 hours after oral dosage in all participants. B) Principal component analysis (PCA) reveals separation between pre and post treatment with probenecid plasma metabolomes. C) Hundreds of metabolites were significantly altered (elevated and decreased) following treatment with probenecid. D) Among the significantly elevated metabolites, 21 subpathways with at least 5 metabolites were enriched, including subpathways traditionally associated with OAT-mediated transport (Primary Bile Acid Metabolism, Phenylalanine Metabolism, Tyrosine Metabolism, Tryptophan Metabolism, etc.).