Figure 6: Multiple metabolites suggested to be OAT substrates are supported by in vivo Oat1 and Oat3 knockout mice.

Twenty-five metabolites elevated in the probenecid-treated human plasma, decreased in the probenecid-treated urine, and elevated in one or both knockout mice. Twenty of these metabolites had associated chemical structures. Fifteen (13 with chemical structures) were common to both knockout mice, while 6 (3 with chemical structures) were unique to the Oat1 knockout mice, and 4 were unique to the Oat3 knockout mice.