Table 1. Toxicity panel.
100 ng of 17-epi-NPD1/17-epi-PD1 methyl ester or vehicle (0.1% ethanol) were administered to mice i.v. in 100 μl of sterile saline, and blood was collected 24 hours later. Serum was analyzed for a panel of common toxicology markers and expressed as the mean ± SD of 3 mice per group. Unpaired, two-tailed t tests were performed for comparisons between vehicle control and 17-epi-NPD1/17-epi-PD1 for each analyte. ALP: alkaline phosphatase, AST: aspartate aminotransferase, ALT: alanine aminotransferase, ALB/GLOB: albumin/globulin, LDH: lactate dehydrogenase.
| Analyte | Vehicle control (mean ± SD) | 17-epi-NPD1/17-epi-PD1 (mean ± SD) | P-value |
|---|---|---|---|
| ALP (U/L) | 147.00 ± 23.52 | 149.33 ± 2.89 | 0.8728 |
|
|
|||
| AST (U/L) | 126.67 ± 57.55 | 177.00 ± 66.09 | 0.3761 |
|
|
|||
| ALT (U/L) | 39.33 ± 11.01 | 70.67 ± 22.50 | 0.0962 |
|
|
|||
| Albumin (g/dL) | 2.87 ± 0.12 | 2.83 ± 0.12 | 0.7415 |
|
|
|||
| Total bilirubin (mg/dL) | 0.17 ± 0.06 | 0.23 ± 0.06 | 0.2302 |
|
|
|||
| Total protein (g/dL) | 5.03 ± 0.21 | 5.00 ± 0.17 | 0.8416 |
|
|
|||
| Globulin (g/dL) | 2.17 ± 0.15 | 2.17 ± 0.06 | >0.9999 |
|
|
|||
| Bilirubin conjugated (mg/dL) | 0.00 ± 0 | 0.00 ± 0 | n/a |
|
|
|||
| ALB/GLOB ratio (g/dL) | 1.33 ± 0.12 | 1.30 ± 0 | 0.6433 |
|
|
|||
| LDH (U/L) | 881.67 ± 34.65 | 1238.67 ± 383.32 | 0.1834 |
|
|
|||
| Bilirubin unconjugated (mg/dL) | 0.17 ± 0.06 | 0.23 ± 0.06 | 0.2302 |