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Summary of EC50 values determined in switch-mediated in vitro cytotoxicity assays with sCAR-Ts.
| EC50 (pM) | R12 | T43 | 402 | 306 | 403 | T22 | 324 | Y31 | R11 | Ctrl | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| K562/ROR1 | Fab-N | 1.4 | 1.4 | 3.5 | 46 | 890 | 150 | 18 | - | 3.7 | - |
| Fab-C | 8.1 | 6.1 | 11 | 120 | 950 | 190 | 19 | - | 260 | - | |
| JeKo-1 | Fab-N | 5.2 | 9.2 | 18 | 620 | - | 4700 | 77 | - | 91 | - |
| Fab-C | 18 | 28 | 71 | - | - | - | 260 | - | - | - | |
| MDA-MB-231 | Fab-N | 6.5 | 13 | 21 | 700 | - | 660 | 130 | - | 160 | - |
| Fab-C | 0.38 | 1.5 | 2.6 | - | - | - | 56 | - | - | - |
