. Author manuscript; available in PMC: 2023 Sep 1.

Published in final edited form as: AJR Am J Roentgenol. 2022 Mar 23;219(3):397–405. doi: 10.2214/AJR.22.27595

Table 1.

Characteristics of Included Nodules

Characteristic	Benign Nodules (n=196)	Malignant Nodules (n=27)	p
Age (y), median (IQR)	62 (58–66)	66 (61 – 70)	.04
Sex, Male Female	127 (65) 69 (35)	16 (59) 11 (41)	.36
Diameter (mm), median (IQR) NLST Reader 1 Reader 2	7.0 (6.5 – 7.5) 7.0 (6.0 – 8.5) 7.0 (6.0 – 8.5)	7.5 (7.0 – 9.0) 9.0 (7.5 – 10.0) 9.0 (8.0 – 10.5)	.002 <.001 <.001
Volume (ml), median (IQR) Reader 1 Reader 2	0.16 (0.11 – 0.27) 0.17 (0.09 – 0.27)	0.30 (0.24 – 0.51) 0.33 (0.24 –0.51)	<.001 <.001
Perifissural location Reader 1 Reader 2	37 (19) 25 (13)	2 (7) 1 (4)	.07 .14
Other subpleural location Reader 1 Reader 2	55 (28) 60 (31)	3 (11) 3 (11)	.04 .02
Triangular, polygonal, or oval shape Reader 1 Reader 2	175 (89) 95 (48)	7 (26) 6 (22)	<.001 .01
Lymph node characteristics^a Reader 1 Reader 2	85 (43) 73 (37)	0 (0) 2 (7)	<.001 <.001

Unless otherwise specified, values represent count with percentage in parentheses.

Defined as exhibiting both (1) perifissural or other subpleural location, and (2) triangular, polygonal, or oval shape.

IQR = interquartile range; NLST = National Lung Screening Trial