Fig. 3.

PET time activity curves and binding kinetics of [¹⁸F]flortaucipir to MAO-A, compared with MAO-A ligand [¹⁸F]FEH. PET time activity curves were generated for [¹⁸F]flortaucipir for rats pre-treated with saline and pargyline (50 mg/kg) (A; n = 4 per group) and for [¹⁸F]-FEH (fluoroethyl-harmol) for rats pre-treated with saline and pargyline (50 mg/kg) (B; n = 3 per group). Data are mean ± SEM. Kinetic binding curves were generated for [¹⁸F]flortaucipir binding to PHF and MAO-A (C) and for [¹⁸F]-FEH (fluoroethyl-harmol) binding to MAO-A (D). Data are mean ± SD. Abbreviations: AVG, average; MAO, monoamine oxidase; n, number of replicates; PET, positron emission tomography; PHF, paired helical filament; SD, standard deviation; SEM, standard error of mean