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. 2022 May 12;49(11):3627–3638. doi: 10.1007/s00259-022-05821-w

Table 2.

Self-absorbed dose rates to the nucleus per unit activity (Gy(Bq*s)-1) depending on radionuclide localization (i.e. cell membrane and cytoplasm) and cellular dimension (i.e. minimum, average and maximum)

Floating set-up (spherical cells)
Dimension Source compartment
Cell membrane Cytoplasm
Lutetium-177 Actinium-225 Lutetium-177 Actinium-225
Minimum 2.02E-04 1.05E-01 3.67E-04 1.78E-01
Average 1.04E-04 5.63E-02 1.98E-04 1.01E-01
Maximum 6.40E-05 3.56E-02 1.23E-04 6.48E-02
Attached cells set-up (ellipsoidal shape)
Dimension Source compartment
Cell membrane Cytoplasm
Lutetium-177 Actinium-225 Lutetium-177 Actinium-225
Minimum 3.43E-04 1.61E-01 2.14E-04 1.09E-01
Average 1.65E-04 8.31E-02 1.16E-04 6.15E-02
Maximum 7.66E-05 4.05E-02 5.89E-05 3.23E-02
Contribution of the radioactive medium
Lutetium-177 Actinium-225
2.30E-11 4.57E-09