Table 3.
Absorbed dose (Gy) accumulated over 7 days (i.e. duration of clonogenic survival assay) of either [177Lu]Lu-PSMA-I&T or [225Ac]Ac-PSMA-I&T treatment. The absorbed dose is reported for 3 cellular dimension assumptions (i.e. average, minimum, and maximum) in order to provide the average and maximum range of variation of the absorbed dose calculations.
| [177Lu-PSMA-I&T | |||
| Dimension | |||
| Concentration (MBq/mL) | Average | Minimum | Maximum |
| 0 | 0 | 0 | 0 |
| 0.1 | 0.74 | 1.48 | 0.37 |
| 0.2 | 1.48 | 2.96 | 0.74 |
| 0.3 | 2.22 | 4.43 | 1.11 |
| 0.4 | 2.96 | 5.91 | 1.48 |
| 0.5 | 3.70 | 7.39 | 1.85 |
| [225Ac]Ac-PSMA-I&T | |||
| Dimension | |||
| Concentration (kBq/mL) | Average | Minimum | Maximum |
| 0 | 0 | 0 | 0 |
| 0.037 | 0.08 | 0.16 | 0.04 |
| 0.1 | 0.22 | 0.42 | 0.11 |
| 0.185 | 0.41 | 0.78 | 0.21 |
| 0.25 | 0.56 | 1.05 | 0.29 |
| 0.37 | 0.83 | 1.55 | 0.42 |
| 0.5 | 1.12 | 2.10 | 0.57 |
| 0.75 | 1.67 | 3.15 | 0.86 |