Fig. 2. CgMLST-based minimum spanning tree visualizing the genetic relationship between isolates from three extra-pulmonary outbreaks and 12 putative pulmonary transmission clusters.
Isolates were previously clustered in six independent studies12, 15, 21, 41–43. Node labels correspond to isolate ID. The size of the nodes is proportional to the number of samples with the same cgMLST profile (i.e. with allelic distance=0). Distances (SNPs in red and alleles in black) between two isolates are displayed on the branches (not to scale). Dashed boxes indicate patients that have attended the same cystic fibrosis (CF) healthcare center at the same time (i.e. putative patient-to-patient transmission event). OM: otitis media.