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. 2022 Aug 23;13:4844. doi: 10.1038/s41467-022-32398-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The top panel is a linear model of the INHBE protein with prodomain and mature domains in gray and brown, respectively. An exon track shows the two exons of the gene (in purple and blue). Predicted loss of function (pLOF) variants identified by exome-sequencing and included in the gene-burden analysis are shown below the exon track, with numbers in parenthesis corresponding to the number of carriers for each allele. The bottom panel shows associations with fat distribution for pLOF variants in INHBE across cohorts. P-values are from two-sided Wald tests. Markers represent the beta estimates while error bars represent 95% confidence intervals. The gray diamond represents meta-analysis estimates. BMI body mass index, WHR waist-hip ratio, pLOF predicted loss of function, AAF alternative allele frequency, UKB UK Biobank, MDCS Malmö Diet and Cancer Study, MCPS Mexico City Prospective Study, AFR African ancestry, SAS south-Asian ancestry, EUR European ancestry, AMR admixed-American ancestry, RR reference-reference homozygous genotype, RA reference-alternative heterozygous genotype, AA alternative-alternative homozygous genotype, CI confidence interval, SD standard deviations, P P-value.