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. 2022 Aug 23;13:4844. doi: 10.1038/s41467-022-32398-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A shows a gene model for INHBE with the predicted loss of function splice acceptor variant (c.299-1G>C) highlighted. B shows a Western blot analysis for INHBE protein in cell lysates and conditioned media from CHO cells transfected with wild-type INHBE or the INHBE c.299-1G>C splice acceptor variant. Full length GST-tagged recombinant INHBE protein (100 ng) was used as a positive control and staining with Ponceau S was used to compare sample loading across samples. The image is representative of one of three technical replicates. Each replicate yielded similar results. Chr chromosome, CHO Chinese hamster ovary, GST Glutathione s-transferase, WT wild type, kDa kilodalton, WB western blot, Ponceau S Ponceau S (Acid Red 112).