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. 2022 Aug 23;13:4946. doi: 10.1038/s41467-022-32243-x

Fig. 2. Comparisons of estimation accuracy and false/true positive rate (FPR/TPR) for identifying linear relationships within an ecosystem.

Fig. 2

The average relative norm loss (Frobenius/Spectral) and FPR/TPR of various correlation methods are shown in a, b, respectively. Synthetic data were generated from negative-binomial (NB) distributions. The X-axis denotes the simulation settings, which are a combination of sample size n, number of taxa d, and the dispersion parameter α. Results are represented by the average of the corresponding measures (Frobenius/Spectral norm loss, or FPR/TPR) ± standard errors (shown as error bars) across 100 simulation runs for each n/d/α setting. Data points are added to the bar charts using dots with jittering. Color and the name of the corresponding correlation methods are shown at the bottom of the graph. The results demonstrate that SECOM and SPIEC-EASI outperformed all existing methods not only in terms of estimation accuracy but also in terms of uniformly small FPR and comparable TPR.