Table 1.
Overview of datasets and final sample sizes used in the analyses.
| Dataset | n | Sample counts per data type |
Analysis steps |
|||||
|---|---|---|---|---|---|---|---|---|
| WGS | Methyl. | RNA-seq | Omics-based metrics calculation | Model building | Model selection and validation | CNV associations | ||
| Estonian OmniExpress sample set (N = 7,750) | ||||||||
| EstBB-MO | 1,066 | 983 | 295 | 382 | + | + | – | – |
| First-degree relatives | 504a | N/A | N/A | N/A | – | – | + | – |
| Lifelines deep (N = ∼1,500) | ||||||||
| LLDeep | 1,383 | N/A | 768 | 1,098 | + | + | – | – |
| Swiss Kidney Project on Genes in Hypertension (N = 1,128) | ||||||||
| SkiPOGH | 466 | N/A | 148 | 405 | + | – | – | – |
| Parent-child pairs | 319 | N/A | N/A | N/A | – | – | + | – |
| Estonian Biobank GSA sample set (N = ∼200,000) | ||||||||
| EstBB-GSA (unrelated) | 89,516 | N/A | N/A | N/A | – | – | – | + |
| MZ twins | 312 | N/A | N/A | N/A | – | – | + | – |
| First-degree relatives | 79,903 | N/A | N/A | N/A | – | – | + | – |
| UK Biobank (N = ∼500,000) | ||||||||
| UKB (unrelated British) | 331,522 | N/A | N/A | N/A | – | – | – | + |
| MZ twins | 302 | N/A | N/A | N/A | – | – | + | – |
| First-degree relatives | 42,032 | N/A | N/A | N/A | – | – | + | – |
N/A, not applicable.
a
Estonian OmniExpress first-degree relatives do not overlap with EstBB-MO samples.