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. 2022 Aug 14;21:69–85. doi: 10.1016/j.bioactmat.2022.07.024

Fig. 3.

Fig. 3

Synthesis and characterization of PEG-PIB (A) Synthesis diagram of PEG-PIB. (B) SEM results of PEG-PIB (red arrow). Scale bar = 100 μm (C) 1H NMR spectrum of PEG-PIB monomer. (D) 1H NMR spectrum of PEG-PIB polymeride. (E) GPC traces of the PEG-PETTC and PEG-PIB. (F) Size distributions and the PDI of PEG-PIB. (G) ζ-potential of PEG-PIB at different pH values. p < 0.05 (one-way ANOVA test) (H) ibuprofen release rate from PEG-PIB with or without esterase at different pH values (pH 7.4, pH 6.8, pH 6.4, pH 6.2). p < 0.05 (two-way ANOVA test) (I) FACS results of rhodamine packaged PEG-PIB endocytosed by the hNPPCs. (J) Immunofluorescence results of hNPPCs treated with FDA at different pH values (pH 7.4, pH 6.8, pH 6.4, pH 6.2), and further added rhodamine packaged PEG-PIB for 30 min to observe the efficiency of endocytosis. Scale bar = 50 μm (K) The quantitative result of Fig. 3J p < 0.05 (one-way ANOVA test) (L) CCK-8 results of the PEG-PIB effect on hNPPCs proliferation. (Student's t-test) (M) ibuprofen release rate from PEG-PIB within the hNPPCs at different pH values (pH 7.4, pH 6.8, pH 6.4, pH 6.2). p < 0.05 (two-way ANOVA test).