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Proposed pathway for the cardioprotective effect of NG against diabetes-induced myocardial injury. Hyperglycemia or HG reduces Nrf2 expression and induces NF-κB expression, resulting in oxidative stress and inflammation. NG, a flavonoid abundant in grapefruit, partially attenuates diabetes-induced heart injury by activating the Nrf2 pathway and inhibiting the NF-κB pathway.
