Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 10;13:963506. doi: 10.3389/fphar.2022.963506

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Yang, Wang, Song, Zhu, Ding, Yang, Sun, Wen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Celastrol alleviated the progression of OA in rat model. (A) Timeline for depicting overall the design of the study. (B) Knee joint diameter of the affected limbs of rats before surgery and 16 weeks after surgery; n = 6. (C) Representative macroscopic appearance of femoral condyles and tibial plateau showed joint damage (red arrow). (D) H&E and S&F staining of medial compartment cartilage and subchondral bone of knee joints; n = 5 (scale bar: 200 μm). (E) H&E staining of synovial membrane of the medial compartment; n = 5 (scale bar: 100 μm). (F–H) Quantitative analysis of cartilage degeneration score, subchondral bone damage score and synovitis inflammation score in three groups, n = 5. All data represent mean ± S.E.M.*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.