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. 2022 Aug 10;13:963506. doi: 10.3389/fphar.2022.963506

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Copyright © 2022 Yang, Wang, Song, Zhu, Ding, Yang, Sun, Wen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol reduced osteophyte formation and bone resorption induced by MCLT+pMMT in vivo. (A) Representative μCT images of frontal, lateral and coronal views of the knee joints from different groups (scale bar: 1 mm). (B) Representative three-dimensional μCT images of subchondral bone and sagittal views of medial compartment subchondral bone (scale bar: 1 mm). (C) Quantitative analysis of BV, BV/TV, Tb.N Tb.Th and Tb. Sp, n = 6. All data represent mean ± S.E.M. *p < 0.05, **p < 0.01 and ***p < 0.001.