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. 2022 Aug 10;13:963506. doi: 10.3389/fphar.2022.963506

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Copyright © 2022 Yang, Wang, Song, Zhu, Ding, Yang, Sun, Wen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol inhibited IL-1β-induced inflammatory mediators in rat chondrocytes. (A) Rat chondrocytes viability for 24 h treated with celastrol at different concentrations examined by CCK-8 kit. (B) The mRNA levels of COX2 in rat chondrocytes were assayed by real-time PCR. (C) Representative Western blot results for COX2 in rat chondrocytes treated as indicated. (D) Quantification of Western blot data from (C). (E,F) Levels of PGE2 and IL-6 were assayed by ELISA. All data represent mean ± S.E.M.*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. All experiments were repeated 3 times.