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. 2022 Aug 10;13:963506. doi: 10.3389/fphar.2022.963506

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Copyright © 2022 Yang, Wang, Song, Zhu, Ding, Yang, Sun, Wen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol inhibited matrix degradation in rat chondrocytes. (A) Representative immunofluorescence staining for Collagen Ⅱ in rat chondrocytes (green: Collagen Ⅱ, blue: DAPI, scale bar:100 μm). (B) Quantification of the immunohistochemical staining data from A. (C) The mRNA levels of MMP13 in rCHs were assayed by real-time PCR. (D) Representative Western blot results for MMP13 in rCHs treated as indicated. (E) Quantification of Western blot data from D. (F) Immunohistochemical staining for CollagenⅡ and MMP13 in the affected joint cartilage of rats from different groups (scale bar:50 μm). All data represent mean ± S.E.M.*p < 0.05, **p < 0.01 and ***p < 0.001. All experiments were repeated 3 times.