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. 2022 Aug 10;13:963506. doi: 10.3389/fphar.2022.963506

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Copyright © 2022 Yang, Wang, Song, Zhu, Ding, Yang, Sun, Wen and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Celastrol inhibited TLR2-triggered signals in rat chondrocytes. (A,B) Interaction diagrams of celastrol docked to TLR2 using Maestro software. (C,F) The mRNA levels of TLR2 and NF-κB in rat chondrocytes were assayed by real-time PCR. (D,G) Western blot results for TLR2, p-NF-κB and NF-κB in rat chondrocytes with or without celastrol. (E,H,I) Quantification of Western blot data from D and G. (J) Immunohistochemical staining for TLR2 in the affected joint cartilage of rats from different groups (scale bar: 50 μm). All data represent mean ± S.E.M. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. All experiments were repeated 3 times.