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. 2022 Aug 10;13:888533. doi: 10.3389/fphar.2022.888533

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Copyright © 2022 Cao, Fu, Zhang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional annotation of the darkturquoise module. (A) GO term enrichment and (B) KEGG pathway analysis of the darkturquoise module. Gene ratio indicates the ratio of the enriched genes in each GO function and KEGG pathway. The color and size of the dot represent p-value adjusted by Benjamini and Hochberg method and the gene number assigned to the corresponding GO term and KEGG pathway, respectively. Functional annotation reveals critical signaling pathways in OA, such as MAPK, TNF, PI3K/Akt, NF-kB, and IL-17 signaling. (C) Heatmap plot of the connectivity of the enriched genes and KEGG pathways.